Variant-specific RT-qPCR for rapid screening of B.1.617 mutations in SARS-CoV-2Article Published on 2022-12-012022-11-15 Journal: The Libyan journal of medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] B.1.617 B.1.617 lineage B.1.617.1 B.1.617.2 collected country Delta delta variant detect Diagnostic method evaluate kappa variant. L452R Libya Lineage multiplex RT-qPCR Mutation mutations new SARS-CoV-2 P681 PCR assay positive sample required RT- qPCR RT-qPCR RT-qPCR assay SARS-CoV-2 screened Sequencing Spread tested variant virus whole genome [DOI] 10.1080/19932820.2022.2121252 PMC 바로가기
SARS-CoV-2 cell entry beyond the ACE2 receptorArticle Published on 2022-11-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor AGTR2 ASGR1 Asymptomatic auxiliary B.1.1.529 B.1.1.7 B.1.617.1 B.1.617.2 binding carried CD147 CD26 cell entry cell surface receptors CLEC4G Cochrane Library COVID19 Delta Delta+ develop English enzyme erythrocyte Evidence explain facilitate host cell Hypoxemia Infection KREMEN1 LDLRAD3 membrane protein MeSH term neuropilin omicron organs Protein receptor receptors S protein SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2. SARSCoV-2 selected target therapeutic agent tissue tropism TMEM30A Transmission variants of SARS-CoV-2 viral entry virus entry [DOI] 10.1007/s11033-022-07700-x PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challengeArticle Published on 2022-10-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] amino acid change antibody B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.1 B.1.617.2 Beta Combination D614G mutation Delta disease severity domain E484K evaluated expressing Gamma greater highlight human-to-human transmission induce L452R Lineage lineages mice moderate mouse-adapted SARS-CoV-2 mRNA vaccine Multiple multiple mutations Mutation mutations N439K N501Y neutralization neutralized Neutralizing activity neutralizing antibody observation omicron other variant P.1 P681R pandemic PROTECT Protein pseudotyped pseudovirus reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serum antibody T478K the S protein Transmissibility vaccination Vaccine variant variants virulent [DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
The basis of mink susceptibility to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 밍크 감수성의 근거Review Published on 2022-09-012022-09-11 Journal: Journal of applied genetics [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals B.1.1.7 B.1.617.1 B.1.617.2 coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Cross-species infection Cross-species transmission D614G death rate disease Evolution highest Host host range Human humans Infection interact issue Minks Mutation Occurrence over Pathogens phenomenon possession Protein raise RBD receptor Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sequence Sequence alignment spike Spike protein spike protein. susceptibility the receptor-binding domain Transmission variants Viral diseases viral pathogenesis viral pathogens virus Y453F [DOI] 10.1007/s13353-022-00689-w PMC 바로가기 [Article Type] Review
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernRBD 및 S2를 표적으로 하는 이중특이성 항체는 SARS-CoV-2 오미크론 및 우려되는 기타 변이체를 잠재적으로 중화합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding bispecific antibodies breadth Breakthrough infection caused concern contagious coronavirus country COVID-19 COVID-19 vaccines Delta demonstrated domain dominant effective Efficacy epitope Epitopes feasible highlighting IMPROVE mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibodies. neutralizing antibody omicron Omicron variant Omicron variants Other other variant other variants parental Prevent Pseudotyped virus RBD Receptor-binding domain reduced respiratory retained SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 WT specificity Spike protein target targeting tested the spike protein therapeutic treat Vaccine variant variants variants of concern VoC VOCs wild-type [DOI] 10.1128/jvi.00775-22 PMC 바로가기 [Article Type] Article
Display of receptor-binding domain of SARS-CoV-2 Spike protein variants on the Saccharomyces cerevisiae cell surfaceArticle Published on 2022-08-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome Antibody neutralization antiserum approach B.1.1.7 B.1.351 B.1.617.1 B.1.671.1 Beta binding candidate Cell cellular immune responses coronavirus disease Coronavirus-2 COVID-19 Culture display domain effective enzyme escaped Express Health humoral inducer initial knocked out mutant Neutralizing activity pandemic Protein RBD RBD binding RBDs Receptor-binding domain reduction robust Saccharomyces cerevisiae SARS-CoV-2 SARS-CoV-2 vaccine spike the receptor-binding domain vaccination Vaccine vaccine candidate variant variants wild-type yeast yeast surface display. [DOI] 10.3389/fimmu.2022.935573 PMC 바로가기
A pyrosequencing protocol for rapid identification of SARS-CoV-2 variantsSARS-CoV-2 변이체의 신속한 식별을 위한 파이로시퀀싱 프로토콜Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha B.1.1 B.1.1.529 B.1.1.7 B.1.351 B.1.525 B.1.617.1 B.1.617.2 B.1.621 Beta circulating circulating variant circulating variants confidence Coronaviridae coronavirus costly Delta differentiation distribution effort Epsilon Eta Gamma geographical regions information Iota lineages MONITOR monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment Mutation Next-generation sequencing NGS omicron Patient protocol pyrosequencing reported respiratory reverse transcription SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 variant Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Surveillance the United State therapy time-consuming United States variant Variant. variants [DOI] 10.1002/jmv.27770 PMC 바로가기 [Article Type] Article
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2SARS-CoV-2 수용체 결합 도메인의 일반적인 변이체와 인간 ACE2 간의 상호작용에 대한 온도의 영향Article Published on 2022-07-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 1:1 ACE2 ACE2 binding acquisition Alpha angiotensin approach B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding Delta dissimilarity experiment high accuracy human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Impact Interaction kinetic L452R mutant Mutation offer omicron parameter parameters powerful tool Protein RBD RBD mutation RBD variants Receptor binding domain reproducibility Spike protein Spike protein receptor binding domain surface plasmon surface plasmon resonance temperature the RBD the SARS-CoV-2 the Spike variant wild type Wuhan [DOI] 10.1038/s41598-022-15215-5 PMC 바로가기 [Article Type] Article
A qualitative RT-PCR assay for the specific identification of the SARS-CoV-2 B.1.1.529 (Omicron) Variant of ConcernSARS-CoV-2 B.1.1.529(Omicron) 변형 우려의 특정 식별을 위한 정성적 RT-PCR 분석Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Alpha Alpha variant Alpha VOC B.1.1.529 B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 Beta can be used circulating clinical sample clinical samples collected Combination concern copy numbers Delta detect develop Epsilon Gamma Genome in silico Iota lineages negative controls non-specific omicron P.1 performed positive replaced REPLACED BY RNA RNA genome RT-PCR RT-PCR assay SARS-CoV-2 Sequencing Specific Specific identification. specificity the SARS-CoV-2 variant virus VoC were used Wuhan [DOI] 10.1016/j.jcv.2022.105191 PMC 바로가기 [Article Type] Article
Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 miceBacillus Calmette-Guérin에 의해 유도된 훈련된 면역은 K18-hACE2 마우스에서 SARS-CoV-2 공격으로부터 보호합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] Activation antibodies B.1.617.1 B.1.617.2 Bacillus Bacillus Calmette-Guérin BCG causal relationship confirmed case COVID-19 experimental evidence Glycolysis Heterologous immune responses Immunity induce Infectious disease Innate innate immune response Innate immunity innate immunity. investigated K18-hACE2 K18-hACE2 mice myeloid cell neutralization pathway PROTECT provide reported resulting robust SARS-CoV-2 SARS-CoV-2 variant the WHO vaccination Vaccine vaccine breakthrough infections variants WT SARS-CoV-2 [DOI] 10.1172/jci.insight.157393 PMC 바로가기 [Article Type] Article